Thursday, October 25, 2018
7:00 – 8:00 AM
Registration
Poster set up
Lytle Foyer
Breakfast
Conference Center A
8:00 – 8:10 AM
Conference Opening/Welcome Remarks
Lijun Xia/Rodger McEver, Wileman Learning Center
8:10 – 10:00 AM
Session I: Biogenesis and Clearance
Wileman Learning Center
Chairs: Gilbert White, MD (Blood Center of Wisconsin), Rodger McEver, MD (OMRF)
20 MIN TALKS
8:10 – 8:30 AM
Role of Platelet GPIbalpha in TPO Production
Heyu Ni, MD,PhD, University of Toronto
Heyu Ni, MD,PhD, University of Toronto
8:30 – 8:50 AM
Mitochondria and platelet cell death
Shawn Jobe, MD, PhD, Blood Center of Wisconsin
Shawn Jobe, MD, PhD, Blood Center of Wisconsin
15 MIN TALKS
8:50 – 9:05 AM
Novel strategies for the use of CRISPR/Cas9 to edit the genes of iPS cells prior to their differentiation into megakaryocytes so as to generate platelets with improved hemostatic effectiveness
Alyssa Moroi, PhD, Blood Center of Wisconsin
Alyssa Moroi, PhD, Blood Center of Wisconsin
9:05 – 9:20 AM
Inter-individual differences in PAR4 activation
Benjamin Tourdot, PhD, University of Michigan Medical School
Benjamin Tourdot, PhD, University of Michigan Medical School
9:20 – 9:35 AM
Role of somatic mutations and clonal thrombopoiesis in immune thrombocytopenia
Sami Ibrahimi, MD, Stephenson Cancer Center, University of Oklahoma Health Science Center
Sami Ibrahimi, MD, Stephenson Cancer Center, University of Oklahoma Health Science Center
9:35 – 9:50 AM
Exomes as a risk factor of cancer-associated thrombosis
Tejasyi Dudiki, PhD, Cleveland Clinic
Tejasyi Dudiki, PhD, Cleveland Clinic
9:50 – 10:05 AM
Coffee break
10:05 – 11:55 PM
Session II: Adhesion, Aggregation, and Secretion
Wileman Learning Center
Chairs: Edward Plow, PhD (Cleveland Clinic – Lerner Research Institute), Peter Newman, PhD (Blood Center of Wisconsin)
Wileman Learning Center
Chairs: Edward Plow, PhD (Cleveland Clinic – Lerner Research Institute), Peter Newman, PhD (Blood Center of Wisconsin)
20 MIN TALKS
10:05 – 10:25 AM
GPIb-IX mechanosensory domain and Bernard-Soulier syndrome
Renhao Li, PhD, Emory University
Renhao Li, PhD, Emory University
10:25 – 10:45 AM
The small GTPase Rap1 as a master regulator of platelet activation: from bench to clinic, and back
Wolfgang Bergmeier, PhD, University of North Carolina School of Medicine
Wolfgang Bergmeier, PhD, University of North Carolina School of Medicine
10:45 – 11:05 AM
A specific phosphorylation event regulates the
function of kindelin-3 in hematopoietic and non-hematopoietic cells
Edward Plow, MD, Cleveland Clinic
function of kindelin-3 in hematopoietic and non-hematopoietic cells
Edward Plow, MD, Cleveland Clinic
15 MIN TALKS
11:05 – 11:20 AM
Maternal anti-αIIb alloantibodies may disrupt
hematopoietic stem cell migration and distribution infetal and neonatal alloimmune thrombocytopenia
Brigitta Elaine Oswald, University of Toronto
hematopoietic stem cell migration and distribution infetal and neonatal alloimmune thrombocytopenia
Brigitta Elaine Oswald, University of Toronto
11:20 – 11:35 AM
Platelet Vesicle-Associated Membrane Proteins (VAMPs) control thrombosis and hemostasis
Smita Joshi, PhD, University of Kentucky Lexington
Smita Joshi, PhD, University of Kentucky Lexington
11:35 – 11:50 AM
New Mechanisms regulating platelet ROS generation
M. Keegan Delaney, PhD, University of Illinois at Chicago
M. Keegan Delaney, PhD, University of Illinois at Chicago
11:50 – 12:05 PM
Stable isotope-resolved metabolomics (SIRM) revealsextensive metabloic reprogramming during platelet activation
Qingjun Wang, PhD, University of Kentucky
College of Medicine
Qingjun Wang, PhD, University of Kentucky
College of Medicine
12:05 – 2:00 PM
Poster session,
Lytle Foyer
Lunch provided concurrently,
Conference Center A
Lytle Foyer
Lunch provided concurrently,
Conference Center A
2:00 – 3:50 PM
Session III: Platelet and Coagulation
Wileman Learning Center
Chairs: Charles Esmon, PhD (OMRF), James Morrissey, PhD (University of Michigan)
Wileman Learning Center
Chairs: Charles Esmon, PhD (OMRF), James Morrissey, PhD (University of Michigan)
20 MIN TALKS
2:00 – 2:20 PM
Platelet TFPIα: The function of an anticoagulant protein in a procoagulant cell
Alan Mast, PhD, Blood Research Institute/Blood Center of Wisconsin
Alan Mast, PhD, Blood Research Institute/Blood Center of Wisconsin
2:20 – 2:40 PM
Plasma and platelet FXIII in venous thrombosis
Alisa S. Wolberg, PhD, UNC School of Medicine at Chapel Hill
Alisa S. Wolberg, PhD, UNC School of Medicine at Chapel Hill
15 MIN TALKS
2:40 – 2:55 PM
Inorganic polyphosphate amplifies HMGB1-mediated von Willebrand factor release and platelet string formation on endothelial cells
Indranil Biswas, PhD, OMRF
Indranil Biswas, PhD, OMRF
2:55 – 3:10 PM
The role of platelet-derived polyphosphate in coagulation
Stephanie Smith, PhD, University of Michigan
Stephanie Smith, PhD, University of Michigan
3:10 – 3:25 PM
Determining the role of platelets in the pathogenesis of venous thrombosis (VT)
Jean Marie Mwiza, PhD, University of North Carolina
Jean Marie Mwiza, PhD, University of North Carolina
3:25 – 3:40 PM
Platelet specific deletion of UCP-2 reduces frequency of thrombus formation
Rhonda Souvenir, PhD, University of Iowa, Craver College of Medicine
Rhonda Souvenir, PhD, University of Iowa, Craver College of Medicine
3:40 – 3:55 PM
Coffee break
3:55 – 5:45 PM
Session IV: Platelets, Diseases, and Animal Models
Wileman Learning Center
Chairs: Xiaoping Du, MD, PhD (University of Illinois at Chicago), Lisa Jennings, PhD (University of Tennessee)
Wileman Learning Center
Chairs: Xiaoping Du, MD, PhD (University of Illinois at Chicago), Lisa Jennings, PhD (University of Tennessee)
20 MIN TALKS
3:55 – 4:15 PM
Platelet pattern recognition receptors, altered-self ligands and atherothrombosis
Eugene Podrez, MD, PhD, Cleveland Clinic – Lerner Research Institute
Eugene Podrez, MD, PhD, Cleveland Clinic – Lerner Research Institute
4:15 – 4:35 PM
Genetic analysis of hemostasis in mice
Nigel Mackman, MD, PhD, University of North Carolina School of Medicine at Chapel Hill
Nigel Mackman, MD, PhD, University of North Carolina School of Medicine at Chapel Hill
4:35 – 4:55 PM
Role of platelet protein disulfide isomerase in platelet-neutrophil interactions under thromboinflammatory conditions
Jaehyung Cho, PhD, University of Illinois at Chicago College of Medicine
Jaehyung Cho, PhD, University of Illinois at Chicago College of Medicine
4:55 – 5:15 PM
α-granule cargo release is initiated by SNARE-dependent matrix decondensation in mouse platelets
Brian Storrie, PhD, University of Arkansas for Medical Sciences
Brian Storrie, PhD, University of Arkansas for Medical Sciences
15 MIN TALKS
5:15 – 5:30 PM
Ticagreior reduces thromboinflammatory markers in patients with pneumonia
Travis Sexton, PhD, University of Kentucky College of Medicine
Travis Sexton, PhD, University of Kentucky College of Medicine
5:30 – 5:45 PM
Targeting thymidine phosphorylase for thrombotic diseases: How far are we?
Wei Li, MD, PhD, Marshall University Joan C. Edwards School of Medicine
Wei Li, MD, PhD, Marshall University Joan C. Edwards School of Medicine
6:00 – 9:00 PM
Conference Reception/Dinner at Oklahoma’s National Cowboy & Western History Museum, with entertainment
Friday, October 26, 2018
7:00 – 8:00 AM
Registration
Poster Session
Lytle Foyer
Breakfast
Conference Cener A
Poster Session
Lytle Foyer
Breakfast
Conference Cener A
8:00 – 9:45 AM
Session V: Platelets, Diseases, and Translational Research
Wileman Learning Center
Chairs: James George, MD (University of Oklahoma), Susan Smyth, MD, PhD (University of Kentucky)
Wileman Learning Center
Chairs: James George, MD (University of Oklahoma), Susan Smyth, MD, PhD (University of Kentucky)
20 MIN TALKS
8:00 – 8:20 AM
Pathogenesis of Thrombotic Microangiopathy
X. Long Zheng, MD/PhD, The University of Alabama Birmingham
X. Long Zheng, MD/PhD, The University of Alabama Birmingham
8:20 – 8:40 AM
Platelets and the Progression of Ovarian Cancer
Vahid Afshar-Kharghan, MD, University of Texas MD Anderson Cancer Center
Vahid Afshar-Kharghan, MD, University of Texas MD Anderson Cancer Center
8:40 – 9:00 AM
Inflammation regulates platelet gene expression
and function..
Matthew Rondina, MD, University of Utah
Health Sciences Center
and function..
Matthew Rondina, MD, University of Utah
Health Sciences Center
9:00 – 9:20 PM
Autocrine activation of human platelets by epidermal growth factor and EGF receptor-dependent tumorigenesis
Thomas Mcintyre, PhD, Lerner Research Institute, Cleveland Clinic
Thomas Mcintyre, PhD, Lerner Research Institute, Cleveland Clinic
15 MIN TALKS
9:20 – 9:35 PM
Targeting 12-LOX for limiting thrombosis without significant effects on bleeding.
Reheman Adili, MD, University of Michigan Medical School
Reheman Adili, MD, University of Michigan Medical School
9:35 – 9:50 PM
Increased activated platelet binding to T cells in lung cancer patients is correlated with history of thrombosis
Claire Meikle, MD, PhD, University of Toledo College of Medicine
Claire Meikle, MD, PhD, University of Toledo College of Medicine
9:45 – 10:00 AM
Coffee break
10:05 – 11:55 AM
Session VI: Emerging Trends
Wileman Learning Center
Chairs: Leslie Parise, PhD (University of North Carolina at Chapel Hill), Evan Sadler, MD, PhD (Washington University School of Medicine)
Wileman Learning Center
Chairs: Leslie Parise, PhD (University of North Carolina at Chapel Hill), Evan Sadler, MD, PhD (Washington University School of Medicine)
20 MIN TALKS
10:05 – 10:25 AM
Inflammasome activation triggers DIC: a novel mechanism of thrombocytopenia in sepsis
Zhenyu Li, MD, PhD, University of Kentucky College of Medicine
Zhenyu Li, MD, PhD, University of Kentucky College of Medicine
10:25 – 10:45 AM
Analysis of protease activated receptor mechanism by hydrogen deuterium exchange
Marvin Nieman, PhD, Case Western Reserve University
Marvin Nieman, PhD, Case Western Reserve University
10:45 – 11:05 AM
Phenotyping platelets in hemodynamic settings of thrombosis and hemostasis
Scott Diamond, PhD, University of Pennsylvania
Scott Diamond, PhD, University of Pennsylvania
11:05 – 11:25 AM
Platelet TGF-β in aortic valve fibrosis
Jasim Ahamed, PhD, OMRF
Jasim Ahamed, PhD, OMRF
15 MIN TALKS
11:25 – 11:40 AM
Identification of highly conserved ADAMTS-13 domains essential for allosteric regulation using phylogenetic and functional analysis
Joshua Muia, PhD, Washington University School of Medicine, St. Louis
Joshua Muia, PhD, Washington University School of Medicine, St. Louis
11:40 – 11:55 AM
Closing Remarks/Adjourn
Wileman Learning Center
Boxed lunch provided
Wileman Learning Center
Boxed lunch provided